API reference
Thiothixene
- CAS number
- 5591-45-7
- Molecular formula
- C23H29N3O2S2
- Molecular weight
- 443.6 g/mol
About this molecule
Thiothixene Hydrochloride is the hydrochloride salt form of thiothixene, a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
- InChIKey
- GFBKORZTTCHDGY-UWVJOHFNSA-N
- SMILES
- CN1CCN(CC1)CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
- Other CAS numbers recorded
- 3313-26-6
- PubChem CID
- 941651
Also known as
thiothixene · Tiotixene · Tiotixeno · Orbinamon · Tiotixenum · Navaron · thiotixene · Thiothixene cis-
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