API reference
TIAGABINE HCl
- CAS number
- 145821-59-6
- Molecular formula
- C20H26ClNO2S2
- Molecular weight
- 412 g/mol
About this molecule
Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is predominantly localized in presynaptic terminals of neurons thereby preventing the reuptake of GABA by the presynaptic endings. Consequently, this increases the level of available GABA within the synaptic cleft, thereby resulting in prolongation of its inhibitory actions. Tiagabine is effective against maximum electroshock seizures and both limbic and generalized tonic-clonic seizures.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride
- InChIKey
- YUKARLAABCGMCN-PKLMIRHRSA-N
- SMILES
- CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl
- PubChem CID
- 91274
Also known as
Tiagabine hydrochloride · TIAGABINE HCl · Gabatril · ABT-569 · Gabitril · Tiagabine (hydrochloride) · C20H26ClNO2S2 · Gabitril (TN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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