API reference
Tioguanine
- CAS number
- 154-42-7
- Molecular formula
- C5H5N5S
- Molecular weight
- 167.19 g/mol
About this molecule
Thioguanine Anhydrous is the anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-amino-3,7-dihydropurine-6-thione
- InChIKey
- WYWHKKSPHMUBEB-UHFFFAOYSA-N
- SMILES
- C1=NC2=C(N1)C(=S)N=C(N2)N
- Other CAS numbers recorded
- 157646-93-0 · 611-67-6
- PubChem CID
- 2723601
Also known as
6-Thioguanine · thioguanine · Tioguanine · 2-Amino-6-mercaptopurine · 6-Mercaptoguanine · 2-Amino-6-purinethiol · Tioguanin · Tabloid
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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