API reference
Tirbanibulin
- CAS number
- 897016-82-9
- Molecular formula
- C26H29N3O3
- Molecular weight
- 431.5 g/mol
About this molecule
Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. On December 14, 2020, tirbanibulin was approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It is marketed under the brand name Klisyri. Actinic keratosis is a chronic condition characterized by lesions, which can potentially transform into invasive squamous cell carcinoma with a risk of 1% over 10 years. Tirbanibulin blocks the molecular pathways that promote the proliferation, survival, and metastasis of malignant cells. Tirbanibulin exhibits antitumour effects in vitro and in vivo and has been investigated for its antitumor efficacy in the management of various cancers, such as prostate cancer and breast cancer.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]-2-pyridinyl]acetamide
- InChIKey
- HUNGUWOZPQBXGX-UHFFFAOYSA-N
- SMILES
- C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4
- PubChem CID
- 23635314
Also known as
Tirbanibulin · KX2-391 · KX-01 · Klisyri · KX01 · KX-2-391 · tirbanibulina · tirbanibuline
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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