API reference
TIVOZANIB HCl
- CAS number
- 682745-41-1
- Molecular formula
- C22H22Cl2N4O6
- Molecular weight
- 509.3 g/mol
About this molecule
Tivozanib Hydrochloride is the hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;hydrate;hydrochloride
- InChIKey
- RQXMKRRBJITKRN-UHFFFAOYSA-N
- SMILES
- CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl.O.Cl
- PubChem CID
- 11547978
Also known as
TIVOZANIB HYDROCHLORIDE · Tivozanib hydrochloride hydrate · Tivozanib HCl hydrate · Tivozanib hydrochloride monohydrate · fotivda · Tivozanib monohydrochloride monohydrate · Tivozanib (hydrochloride hydrate) · (TIVOZANIB HYDROCHLORIDE HYDRATE
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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