API reference
Topiramate
- CAS number
- 97240-79-4
- Molecular formula
- C12H21NO8S
- Molecular weight
- 339.36 g/mol
About this molecule
Topiramate is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate
- InChIKey
- KJADKKWYZYXHBB-XBWDGYHZSA-N
- SMILES
- CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
- PubChem CID
- 5284627
Also known as
topiramate · Topamax · Epitomax · Topamax Sprinkle · Topina · Tipiramate · Topiramato · Topiramatum
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