API reference
TOPOTECAN HCl
- CAS number
- 119413-54-6
- Molecular formula
- C23H24ClN3O5
- Molecular weight
- 457.9 g/mol
About this molecule
Topotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
- InChIKey
- DGHHQBMTXTWTJV-BQAIUKQQSA-N
- SMILES
- CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
- Other CAS numbers recorded
- 1067286-75-2
- PubChem CID
- 60699
Also known as
TOPOTECAN HYDROCHLORIDE · Topotecan Hcl · Nogitecan hydrochloride · Evotopin · Topotecan teva · Topotecan Actavis · Topotecan Hospira · potactasol
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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