API reference
TRIENTINE HCl
- CAS number
- 38260-01-4
- Molecular formula
- C6H20Cl2N4
- Molecular weight
- 219.15 g/mol
About this molecule
Trientine Hydrochloride is the hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride
- InChIKey
- WYHIICXRPHEJKI-UHFFFAOYSA-N
- SMILES
- C(CNCCNCCN)N.Cl.Cl
- PubChem CID
- 71433
Also known as
Trientine hydrochloride · Triethylenetetramine dihydrochloride · Syprine · Trientine Dihydrochloride · Metalite · 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, dihydrochloride · Triethylene tetramine dihydrochloride · CLOVIQUE
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