API reference
Trimethoprim
- CAS number
- 738-70-5
- Molecular formula
- C14H18N4O3
- Molecular weight
- 290.32 g/mol
About this molecule
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of urinary tract infections. It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
- InChIKey
- IEDVJHCEMCRBQM-UHFFFAOYSA-N
- SMILES
- COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
- PubChem CID
- 5578
Also known as
trimethoprim · Proloprim · Trimpex · Trimetoprim · Monotrim · Trimopan · 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine · Wellcoprim
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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