API reference
Tucatinib
- CAS number
- 937263-43-9
- Molecular formula
- C26H24N8O2
- Molecular weight
- 480.5 g/mol
About this molecule
Tucatinib is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Tucatinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 6-N-(4,4-dimethyl-5H-1,3-oxazol-2-yl)-4-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine
- InChIKey
- SDEAXTCZPQIFQM-UHFFFAOYSA-N
- SMILES
- CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5
- PubChem CID
- 51039094
Also known as
Tucatinib · Irbinitinib · Tukysa · ONT-380 · tucatinibum · 6-DIAMINE · Irbinitinib; ARRY-380; ONT-380 · Tukysa (TN)
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