API reference
Vericiguat
- CAS number
- 1350653-20-1
- Molecular formula
- C19H16F2N8O2
- Molecular weight
- 426.4 g/mol
About this molecule
Vericiguat is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating activity. Upon oral administration, vericiguat directly stimulates the catalytic activity of sGC and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This results in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to nitric oxide (NO) binding to heme. Vericiguat stimulates sGC independently of and synergistically with NO.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
- InChIKey
- QZFHIXARHDBPBY-UHFFFAOYSA-N
- SMILES
- COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N
- PubChem CID
- 54674461
Also known as
Vericiguat · Verquvo · vericiguatum · 814-370-3 · Veicigguat · Verquvo (TN) · Vericiguat (Standard) · Vericiguat (JAN/USAN/INN)
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