API reference
Vismodegib
- CAS number
- 879085-55-9
- Molecular formula
- C19H14Cl2N2O3S
- Molecular weight
- 421.3 g/mol
About this molecule
Vismodegib is an orally bioavailable, small molecule inhibitor of SMO and the Hedgehog (Hh) pathway, with potential antineoplastic activity. Upon oral administration, vismodegib targets, binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide
- InChIKey
- BPQMGSKTAYIVFO-UHFFFAOYSA-N
- SMILES
- CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
- PubChem CID
- 24776445
Also known as
Vismodegib · Erivedge · HhAntag691 · vismodegibum · L01XX43 · Erivedge (TN) · C19H14Cl2N2O3S · VIS
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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