API reference
Zileuton
- CAS number
- 111406-87-2
- Molecular formula
- C11H12N2O2S
- Molecular weight
- 236.29 g/mol
About this molecule
Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
- InChIKey
- MWLSOWXNZPKENC-UHFFFAOYSA-N
- SMILES
- CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O
- PubChem CID
- 60490
Also known as
ZILEUTON · Zyflo · Leutrol · Zyflo CR · Zileutonum · N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea · (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea · 1-(1-(1-benzothiophen-2-yl)ethyl)-1-hydroxyurea
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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