API reference
Zoledronate disodium
- CAS number
- 131654-46-1
- Molecular formula
- C5H8N2Na2O7P2
- Molecular weight
- 316.05 g/mol
About this molecule
Zoledronate Disodium is the disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-2-imidazol-1-ylethyl]phosphinate
- InChIKey
- OPQQEYHAVUNQNA-UHFFFAOYSA-L
- SMILES
- C1=CN(C=N1)CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
- Other CAS numbers recorded
- 165800-07-7
- PubChem CID
- 6099949
Also known as
Zoledronate disodium · Zoledronate disodium anhydrous
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