API reference
Zoledronic acid
- CAS number
- 118072-93-8
- Molecular formula
- C5H10N2O7P2
- Molecular weight
- 272.09 g/mol
About this molecule
Zoledronic Acid Anhydrous is anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
- InChIKey
- XRASPMIURGNCCH-UHFFFAOYSA-N
- SMILES
- C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
- PubChem CID
- 68740
Also known as
Zoledronic acid · Zoledronate · Zometa · Reclast · Aclasta · (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid · Zoledronic Acid Anhydrous · Anhydrous Zoledronic Acid
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