Acetaminophen / Chlorpheniramine / Dextromethorphan / Phenylephrine

What it is and how it works

Paracetamol relieves pain and fever; chlorphenamine is a sedating H1-antihistamine; dextromethorphan suppresses the cough reflex centrally; phenylephrine is an alpha-1 agonist nasal decongestant.

Indications

Short-term symptomatic relief of common cold and influenza symptoms including fever, nasal congestion, rhinorrhoea and dry, non-productive cough.

Contraindications

Hypersensitivity to any component; severe hypertension or coronary artery disease; use with or within 14 days of MAO inhibitors; severe hepatic impairment; young children (under 6 years) for cough and cold combinations.

Warnings and precautions

Avoid other paracetamol-containing products. May cause drowsiness; avoid alcohol and driving. Use with caution in hypertension, hyperthyroidism, diabetes, glaucoma and urinary retention; dextromethorphan may interact with serotonergic drugs.

Pregnancy

Generally avoided in pregnancy, particularly in the first trimester.

Storage and supply

Store below 25 °C, protected from light; do not freeze.

Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.