Finished product reference
Dihydrotachysterol
Solution · Oral · 1 mg/1mL · 15 mL
- List code
- 52045
- Pharmacologic class
- Vitamin D analogue
What it is and how it works
Dihydrotachysterol is a synthetic reduced analogue of vitamin D2 that is hydroxylated in the liver to its active form without requiring renal 1-alpha-hydroxylation. It increases intestinal calcium absorption and mobilises calcium from bone, raising plasma calcium.
Indications
Hypocalcaemia due to hypoparathyroidism (idiopathic or post-operative) and pseudohypoparathyroidism; some forms of vitamin D-resistant rickets and renal osteodystrophy.
Dosage and administration (summary)
Dosing is individualised by the specialist according to plasma calcium, with higher initial doses followed by a lower maintenance dose; frequent monitoring of plasma calcium is essential.
Contraindications
Hypercalcaemia, vitamin D toxicity and hypersensitivity to the substance.
Warnings and precautions
Has a narrow therapeutic margin and a prolonged action, so hypercalcaemia may persist for weeks after overdose; monitor plasma calcium regularly, especially at the start of treatment and after dose changes. Use with caution in renal impairment, nephrolithiasis and with digoxin or thiazide diuretics.
Pregnancy
Use only when clearly needed with careful calcium monitoring; excessive doses may harm the fetus.
Storage and supply
Store below 25 °C, protected from light.
Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.
Other presentations of the same active ingredient
Reference information for professional sourcing and registration enquiries, not medical advice or a promotion. Drug information is condensed from US FDA prescribing information (public domain, via openFDA and DailyMed) and does not replace the product’s approved labelling in Iran. Availability, origin and documentation are confirmed per enquiry.
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