Isoflurane

Indications

1. INDICATIONS AND USAGE Isoflurane, USP liquid for inhalation may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia. Isoflurane, USP liquid for inhalation, a general anesthetic, is an inhalation agent indicated for induction and maintenance of general anesthesia.

Dosage and administration (summary)

2. DOSAGE AND ADMINISTRATION Isoflurane, USP liquid for inhalation should be administered only by persons trained in the administration of general anesthesia. Isoflurane, USP liquid for inhalation should only be delivered using a vaporizer specifically designed and designated for use with isoflurane. The administration of general anesthesia must be individualized and titrated based on the patient's age and clinical status. Important Dosage and Administration Information Isoflurane should be administered only by persons trained in the administration of general anesthesia.

Contraindications

4. CONTRAINDICATIONS Isoflurane, USP liquid for inhalation is contraindicated in patients: in whom general anesthesia is contraindicated. with known sensitivity to isoflurane, USP liquid for inhalation or to other halogenated agents . with known or suspected genetic susceptibility to malignant hyperthermia .

Warnings and precautions

5. WARNINGS AND PRECAUTIONS Malignant Hyperthermia : Malignant hyperthermia may occur, especially in individuals with known or suspected susceptibility based on genetic factors or family history. Discontinue triggering agents, administer intravenous dantrolene sodium, and apply supportive therapies. Perioperative Hyperkalemia : Perioperative hyperkalemia may occur. Patients with latent or overt neuromuscular disease, particularly with Duchenne muscular dystrophy, appear to be most vulnerable. Early, aggressive intervention is recommended.

Pregnancy

Pregnancy Risk Summary There are no adequate and well-controlled studies in pregnant women. In animal reproduction studies, embryofetal toxicity was noted in pregnant mice exposed to 0.075% (increased post implantation losses) and 0.3% isoflurane (increased post implantation losses and decreased livebirth index) during organogenesis.

Storage and supply

Storage Store at controlled room temperature 15°-30°C (59°-86°F).

Source: Isoflurane (Isoflurane, (Volatile For Inhalation)) — US FDA prescribing information, 2026-03-30, DailyMed. Summarised and shortened; the full label governs. Iranian registration, indications and labelling may differ.