Isoproterenol Hydrochloride

What it is and how it works

Mechanism of Action Isoproterenol is a potent nonselective beta-adrenergic agonist with very low affinity for alpha‑adrenergic receptors.

Indications

Isoproterenol hydrochloride injection is indicated: • To improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output • For bronchospasm occurring during anesthesia INDICATIONS AND USAGE Isoproterenol hydrochloride injection is a beta-adrenergic agonist indicated: • To improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output • For treatment of bronchospasm occurring during anesthesia

Dosage and administration (summary)

Initiate Isoproterenol hydrochloride injection at the lowest recommended dose and increase gradually based on patient response Recommended initial dosage: •Shock: 0.5 mcg to 5 mcg per minute as an intravenous infusion •Bronchospasm: 10 mcg to 20 mcg intravenous injection General Considerations Inspect visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if the injection is pinkish or darker than slightly yellow or contains a precipitate. Discard any unused portion. Diluted solution should be used immediately. Unused material should be discarded.

Contraindications

Isoproterenol hydrochloride injection is contraindicated in patients with: • Tachycardia • Ventricular arrhythmias • Angina pectoris CONTRAINDICATIONS Isoproterenol hydrochloride injection is contraindicated in patients with: • Tachycardia • Ventricular arrhythmias • Angina pectoris

Warnings and precautions

• Cardiac arrhythmias and ischemia may be induced by Isoproterenol Hydrochloride Injection • Sulfite: Isoproterenol Hydrochloride Injection contains metabisulfite, which may cause allergic reaction Cardiac Arrhythmias and Ischemia Isoproterenol may induce cardiac arrhythmias and myocardial ischemia in patients, especially patients with coronary artery disease, or cardiomyopathy.

Pregnancy

Pregnancy Risk Summary Prolonged experience with isoproterenol use in pregnant women over several decades, based on published literature, do not identify a drug associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.

Storage and supply

Number Container Concentration Fill Quantity 10702-364-05 Single-dose Vial 1 mg/5 mL (0.2 mg/mL) 5 mL 5 mL single-dose vial x 10 vials 10702-364-51 Carton of 10 vials 1 mg/5 mL (0.2 mg/mL) 5 mL 5 mL single-dose vial x 10 vials Protect from light. Keep in opaque container until used. Store at 20º to 25ºC (68º to 77ºF).

Source: Isoproterenol Hydrochloride (Isoproterenol Hydrochloride) — US FDA prescribing information, 2026-03-17, DailyMed. Summarised and shortened; the full label governs. Iranian registration, indications and labelling may differ.