Perphenazine

Indications

INDICATIONS AND USAGE Perphenazine tablets, USP are indicated for use in the treatment of schizophrenia and for the control of severe nausea and vomiting in adults. Perphenazine tablets, USP have not been shown effective for the management of behavioral complications in patients with mental retardation.

Dosage and administration (summary)

DOSAGE AND ADMINISTRATION Dosage must be individualized and adjusted according to the severity of the condition and the response obtained. As with all potent drugs, the best dose is the lowest dose that will produce the desired clinical effect. Since extrapyramidal symptoms increase in frequency and severity with increased dosage, it is important to employ the lowest effective dose. These symptoms have disappeared upon reduction of dosage, withdrawal of the drug, or administration of an antiparkinsonian agent.

Contraindications

CONTRAINDICATIONS Perphenazine products are contraindicated in comatose or greatly obtunded patients and in patients receiving large doses of central nervous system depressants (barbiturates, alcohol, narcotics, analgesics, or antihistamines); in the presence of existing blood dyscrasias, bone marrow depression, or liver damage; and in patients who have shown hypersensitivity to perphenazine products, their components, or related compounds.

Warnings and precautions

WARNINGS Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Perphenazine tablets, USP are not approved for the treatment of patients with dementia-related psychosis ( see BOXED WARNING ). Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements, may develop in patients treated with antipsychotic drugs. Older patients are at increased risk for development of tardive dyskinesia.

Storage and supply

HOW SUPPLIED Perphenazine Tablets USP, 2 mg are white to off white, round, biconvex, film coated tablet debossed with '5' on one side and '91' on other side and are supplied as follows: NDC 70771-1041-1 in bottles of 100 tablets NDC 70771-1041-5 in bottles of 500 tablets NDC 70771-1041-4 in unit-dose blister cartons of 100 (10 x 10) unit-dose table…

Source: Perphenazine (Perphenazine) — US FDA prescribing information, 2024-11-14, DailyMed. Summarised and shortened; the full label governs. Iranian registration, indications and labelling may differ.