Phenylephrine / Zinc

What it is and how it works

Phenylephrine, a sympathomimetic alpha-1 agonist, constricts conjunctival blood vessels and reduces redness, while zinc sulfate has a mild astringent action that precipitates surface proteins and reduces mucus and irritation.

Indications

Temporary relief of redness, irritation and discomfort of the eye due to minor irritants such as dust, smoke, wind, swimming or allergic conjunctivitis.

Dosage and administration (summary)

Topical ophthalmic: usually 1–2 drops into the affected eye(s) up to four times daily, for short-term use only.

Contraindications

Angle-closure glaucoma or narrow anterior chamber angle, hypersensitivity to any component, and concomitant or recent MAOI therapy.

Warnings and precautions

Prolonged or frequent use may cause rebound conjunctival hyperaemia. Use with caution in hypertension, cardiovascular disease, hyperthyroidism and diabetes. Seek medical advice if pain, visual change or redness persists for more than 72 hours; remove soft contact lenses before use.

Pregnancy

Use only if clearly needed; systemic absorption is low.

Storage and supply

Store below 25 °C, protected from light; discard within 4 weeks of opening.

Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.