Rocuronium Bromide

Indications

Rocuronium bromide injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Rocuronium bromide injection is a nondepolarizing neuromuscular blocking agent indicated as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Dosage and administration (summary)

To be administered only by experienced clinicians or adequately trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents. Individualize the dose for each patient. Peripheral nerve stimulator recommended for determination of drug response and need for additional doses, and to evaluate recovery. Store rocuronium bromide injection with cap and ferrule intact and in a manner that minimizes the possibility of selecting the wrong product. Tracheal intubation : Recommended initial dose is 0.6 mg/kg. Rapid sequence intubation : 0.6 to 1.2 mg/kg.

Contraindications

Rocuronium bromide injection is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents . Hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents.

Warnings and precautions

Appropriate Administration and Monitoring : Use only if facilities for intubation, mechanical ventilation, oxygen therapy, and an antagonist are immediately available. Anaphylaxis : Severe anaphylaxis has been reported. Consider cross-reactivity among neuromuscular blocking agents. Risk of Death due to Medication Errors : Accidental administration can cause death. Need for Adequate Anesthesia : Must be accompanied by adequate anesthesia or sedation. Residual Paralysis : Consider using a reversal agent in cases where residual paralysis is more likely to occur.

Storage and supply

Rocuronium bromide injection is a sterile, nonpyrogenic, isotonic solution that is clear, colorless to yellow/orange and is supplied as follows: Rocuronium bromide injection multiple dose vials containing 50 mg/ 5 mL and 100 mg/10 mL (10 mg/mL) rocuronium bromide injection.

Source: Rocuronium Bromide (Rocuronium Bromide) — US FDA prescribing information, 2025-06-03, DailyMed. Summarised and shortened; the full label governs. Iranian registration, indications and labelling may differ.