API reference
Bempedoic acid
- CAS number
- 738606-46-7
- Molecular formula
- C19H36O5
- Molecular weight
- 344.5 g/mol
About this molecule
Bempedoic Acid is an orally bioavailable prodrug and inhibitor of adenosine triphosphate-citrate lyase (ACL), with anti-hyperlipidemic activity. Upon oral administration, bempedoic acid becomes activated to its thioester form with coenzyme A (CoA) by the enzyme very long-chain acyl-CoA synthetase 1 (ACSVL1; SLC27A2) in the liver. The activated form inhibits ACL, thereby preventing the liver's biosynthesis of cholesterol. This lowers low-density lipoprotein cholesterol (LDL-C) levels. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
- InChIKey
- HYHMLYSLQUKXKP-UHFFFAOYSA-N
- SMILES
- CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O
- PubChem CID
- 10472693
Also known as
bempedoic acid · 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid · Nexletol · acido bempedoico · acide bempedoique · acidum bempedoicum · Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl- · NEXLIZET COMPONENT BEMPEDOIC ACID
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