API reference
Binimetinib
- CAS number
- 606143-89-9
- Molecular formula
- C17H15BrF2N4O3
- Molecular weight
- 441.2 g/mol
About this molecule
Binimetinib is an orally available inhibitor of mitogen-activated protein kinase kinase 1 and 2 (MEK1/2) with potential antineoplastic activity. Binimetinib, noncompetitive with ATP, binds to and inhibits the activity of MEK1/2. Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling. This may eventually lead to an inhibition of tumor cell proliferation and an inhibition in production of various inflammatory cytokines including interleukin-1, -6 and tumor necrosis factor. MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
- InChIKey
- ACWZRVQXLIRSDF-UHFFFAOYSA-N
- SMILES
- CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
- Other CAS numbers recorded
- 1073666-70-2
- PubChem CID
- 10288191
Also known as
Binimetinib · MEK162 · ARRY-162 · Mektovi · MEK-162 · binimetinibum · L01XE41 · ARRY 162
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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