API reference
Idelalisib
- CAS number
- 870281-82-6
- Molecular formula
- C22H18FN7O
- Molecular weight
- 415.4 g/mol
About this molecule
Idelalisib is an orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one
- InChIKey
- IFSDAJWBUCMOAH-HNNXBMFYSA-N
- SMILES
- CC[C@@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
- PubChem CID
- 11625818
Also known as
Idelalisib · CAL-101 · Zydelig · CAL101 · idelalisibum · L01XX47 · Phosphoinositide-3 Kinase Delta Inhibitor CAL-101 · CAL 101
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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