API reference
Larotrectinib sulfate
- CAS number
- 1223405-08-0
- Molecular formula
- C21H24F2N6O6S
- Molecular weight
- 526.5 g/mol
About this molecule
Larotrectinib Sulfate is the sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide;sulfuric acid
- InChIKey
- PXHANKVTFWSDSG-QLOBERJESA-N
- SMILES
- C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O
- PubChem CID
- 67330085
Also known as
Larotrectinib sulfate · LOXO-101 sulfate · ARRY-470 sulfate · LOXO 101 sulfate · ARRY 470 Sulfate · LOXO-101 (sulfate) · Larotrectinib sulphate · Vitrakvi (TN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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