API reference
Letrozole
- CAS number
- 112809-51-5
- Molecular formula
- C17H11N5
- Molecular weight
- 285.3 g/mol
About this molecule
Letrozole is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
- InChIKey
- HPJKCIUCZWXJDR-UHFFFAOYSA-N
- SMILES
- C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
- PubChem CID
- 3902
Also known as
letrozole · Femara · Letrozol · Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis- · 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile · letrozolum · Letrozole Tablets · KISQALI FEMARA CO-PACK COMPONENT LETROZOLE
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