API reference
Lomustine
- CAS number
- 13010-47-4
- Molecular formula
- C9H16ClN3O2
- Molecular weight
- 233.69 g/mol
About this molecule
Lomustine is only found in individuals that have used or taken this drug. It is an alkylating agent of value against both hematologic malignancies and solid tumors. Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA (at the O6 position of guanine-containing bases) and RNA, thus inducing cytotoxicity. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents. As lomustine is a nitrosurea, it may also inhibit several key processes such as carbamoylation and modification of cellular proteins.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
- InChIKey
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N
- SMILES
- C1CCC(CC1)NC(=O)N(CCCl)N=O
- PubChem CID
- 3950
Also known as
lomustine · 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea · Belustine · CeeNU · CCNU · Cecenu · CINU · Chloroethylcyclohexylnitrosourea
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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