API reference
Macitentan
- CAS number
- 441798-33-0
- Molecular formula
- C19H20Br2N6O4S
- Molecular weight
- 588.3 g/mol
About this molecule
Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
- InChIKey
- JGCMEBMXRHSZKX-UHFFFAOYSA-N
- SMILES
- CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br
- PubChem CID
- 16004692
Also known as
Macitentan · Opsumit · Actelion-1 · macitentanum · OPSYNVI COMPONENT MACITENTAN · C02KX04 · Opsumit (TN) · C19H20Br2N6O4S
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