API reference
Methotrexate
- CAS number
- 59-05-2
- Molecular formula
- C20H22N8O5
- Molecular weight
- 454.4 g/mol
About this molecule
Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast cancer and non-Hodgkin's lymphoma. Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
- InChIKey
- FBOZXECLQNJBKD-ZDUSSCGKSA-N
- SMILES
- CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
- Other CAS numbers recorded
- 133073-73-1 · 102613-64-9
- PubChem CID
- 126941
Also known as
methotrexate · Rheumatrex · Amethopterin · Metatrexan · Hdmtx · Methylaminopterinum · Methotrexatum · Metotrexato
Related entries in the range
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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