API reference
Methotrexate disodium
- CAS number
- 7413-34-5
- Molecular formula
- C20H20N8Na2O5
- Molecular weight
- 498.4 g/mol
About this molecule
Methotrexate is only found in individuals that have used or taken this drug. It is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [PubChem]Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.
Source: Toxin and Toxin Target Database (T3DB), via PubChem.
Identifiers
- IUPAC name
- disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
- InChIKey
- DASQOOZCTWOQPA-GXKRWWSZSA-L
- SMILES
- CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
- Other CAS numbers recorded
- 15475-56-6
- PubChem CID
- 11329481
Also known as
Methotrexate disodium salt · METHOTREXATE SODIUM · Sodium methotrexate · Disodium methotrexate · Abitrexate · Trexall · Methotrexate Lpf · Folex Pfs
Related entries in the range
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