API reference
Methylprednisolone acetate
- CAS number
- 53-36-1
- Molecular formula
- C24H32O6
- Molecular weight
- 416.5 g/mol
About this molecule
Methylprednisolone Acetate is the acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
- InChIKey
- PLBHSZGDDKCEHR-LFYFAGGJSA-N
- SMILES
- C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O
- PubChem CID
- 5877
Also known as
Methylprednisolone acetate · Depo-medrol · Depo-Medrate · M-Predrol · Medrol acetate · Depo-Medrone · Methylprednisolone 21-acetate · 6alpha-Methylprednisolone acetate
Related entries in the range
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