API reference
Miltefosine
- CAS number
- 58066-85-6
- Molecular formula
- C21H46NO4P
- Molecular weight
- 407.6 g/mol
About this molecule
Miltefosine is an orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
- InChIKey
- PQLXHQMOHUQAKB-UHFFFAOYSA-N
- SMILES
- CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C
- PubChem CID
- 3599
Also known as
Miltefosine · Hexadecylphosphocholine · Miltex · Impavido · HDPC · Miltefosina · Hexadecylphosphorylcholine · Miltefosinum
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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