API reference
Nabumetone
- CAS number
- 42924-53-8
- Molecular formula
- C15H16O2
- Molecular weight
- 228.29 g/mol
About this molecule
Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID). It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a degree of cyclooxygenase-2 selectivity (COX-2), nabumetone still produces significant adverse effects in the GI tract. The molecule itself is a pro-drug with its 6-methoxy-2-naphthylacetic acid (6-MNA) metabolite acting as a potent COX inhibitor similar in structure to [naproxen]. Nabumetone was developed by Smithkline Beecham under the trade name Relafen and first received FDA approval in December, 1991.
Source: DrugBank, via PubChem.
Identifiers
- IUPAC name
- 4-(6-methoxynaphthalen-2-yl)butan-2-one
- InChIKey
- BLXXJMDCKKHMKV-UHFFFAOYSA-N
- SMILES
- CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC
- PubChem CID
- 4409
Also known as
nabumetone · 4-(6-methoxynaphthalen-2-yl)butan-2-one · Relafen · Nabumetona · 4-(6-Methoxy-2-naphthyl)-2-butanone · nabumeton · Nabumetonum · 4-(6-Methoxy-2-naphthalenyl)-2-butanone
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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