API reference
PONATINIB HCl
- CAS number
- 1114544-31-8
- Molecular formula
- C29H28ClF3N6O
- Molecular weight
- 569 g/mol
About this molecule
Ponatinib Hydrochloride is the hydrochloride salt form of an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
- InChIKey
- BWTNNZPNKQIADY-UHFFFAOYSA-N
- SMILES
- CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl
- PubChem CID
- 46908927
Also known as
Ponatinib hydrochloride · Iclusig · Ponatinib HCl · Ponatinib Mono-hydrochloride · Ponatinib (HCl salt) · Ponatinib (hydrochloride) · C29H28ClF3N6O · Iclusig (TN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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