API reference
Selpercatinib
- CAS number
- 2152628-33-4
- Molecular formula
- C29H31N7O3
- Molecular weight
- 525.6 g/mol
About this molecule
Selpercatinib is an oral selective inhibitor of the tyrosine kinase receptor encoded by RET (rearranged during transfection), a proto-oncogene which is mutated or altered in many cancers such a medullary thyroid cancer and non-small cell lung cancer. Serum aminotransferase elevations are common during therapy with selpercatinib and can lead to dose modifications or drug discontinuation, but clinically apparent liver injury with jaundice has not been described with its use.
Source: LiverTox, via PubChem.
Identifiers
- IUPAC name
- 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
- InChIKey
- XIIOFHFUYBLOLW-UHFFFAOYSA-N
- SMILES
- CC(C)(COC1=CN2C(=C(C=N2)C#N)C(=C1)C3=CN=C(C=C3)N4CC5CC(C4)N5CC6=CN=C(C=C6)OC)O
- PubChem CID
- 134436906
Also known as
Selpercatinib · Retevmo · Ret inhibitor loxo-292 · selpercatinibum · RET Kinase Inhibitor LOXO-292 · 843-660-2 · Loxo-292 · LOXO292
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
Tell us the grade, the quantity and the market.
Send the molecule or ingredient, the specification and the destination. We reply from Tehran with the questions, the documents and the next step.