API reference
Zanubrutinib
- CAS number
- 1691249-45-2
- Molecular formula
- C27H29N5O3
- Molecular weight
- 471.5 g/mol
About this molecule
Zanubrutinib is an inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, zanubrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.
Source: NCI Thesaurus (NCIt), via PubChem.
Identifiers
- IUPAC name
- (7S)-2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
- InChIKey
- RNOAOAWBMHREKO-QFIPXVFZSA-N
- SMILES
- C=CC(=O)N1CCC(CC1)[C@@H]2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N
- Other CAS numbers recorded
- 1651179-04-2
- PubChem CID
- 135565884
Also known as
Zanubrutinib · Brukinsa · zanubrutinibum · BTK-InhB · Brukinsa (TN) · Zanubrutinib (Standard) · Zanubrutinib (JAN/USAN/INN)
Chemical data on this page is drawn from PubChem (National Library of Medicine) and is provided for identification only. Hanpars does not hold stock of every substance listed; availability, grade, documentation and regulatory status are confirmed per enquiry.
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