Finished product reference
Dextrose / Ethanol
Injection, Solution · Intravenous · 5 %/5 % · 1000 mL
- List code
- 394
- Pharmacologic class
- Intravenous carbohydrate–alcohol solution (ethanol in glucose)
What it is and how it works
A solution of ethanol (typically 5%) in glucose (dextrose) for intravenous infusion. Ethanol is a competitive substrate for alcohol dehydrogenase, preventing formation of toxic metabolites of methanol and ethylene glycol, and also supplies calories; glucose provides additional energy and free water.
Indications
Antidote in methanol or ethylene glycol poisoning when fomepizole is unavailable; historically as a source of calories and for sedation in specialised settings.
Dosage and administration (summary)
Dosing is individualised according to protocol, aiming at a target blood ethanol concentration (around 1–1.5 g/L in toxic alcohol poisoning) with frequent blood ethanol and glucose monitoring; dose requirements increase during haemodialysis.
Contraindications
Hypersensitivity to the components, epilepsy, coma due to other causes, urinary tract infection, and concurrent disulfiram or metronidazole; caution in hepatic disease.
Warnings and precautions
Causes CNS depression, hypoglycaemia (especially in children and malnourished patients), hyponatraemia and fluid overload; vital signs, glucose and electrolytes must be monitored. Thrombophlebitis can occur with peripheral infusion. Interacts with other CNS depressants.
Pregnancy
Ethanol crosses the placenta; use only when the benefit in poisoning outweighs the risk.
Storage and supply
Store below 25 °C; do not freeze.
Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.
Reference information for professional sourcing and registration enquiries, not medical advice or a promotion. Drug information is condensed from US FDA prescribing information (public domain, via openFDA and DailyMed) and does not replace the product’s approved labelling in Iran. Availability, origin and documentation are confirmed per enquiry.
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