Meglumine Compound

What it is and how it works

A mixture of the meglumine and sodium salts of amidotrizoic (diatrizoic) acid, a tri-iodinated benzoic acid derivative. The iodine atoms absorb X-rays, opacifying the vessels, body cavities or gastrointestinal tract into which the solution is introduced; it is excreted unchanged, mainly by the kidneys.

Indications

Injection: radiographic procedures such as urography, angiography and other contrast examinations. Oral/rectal solution: radiographic examination of the gastrointestinal tract, particularly when barium sulfate is contraindicated (e.g. suspected perforation).

Dosage and administration (summary)

Dose, concentration and route are individualised by the radiologist according to the examination and the patient’s age, weight and renal function.

Contraindications

Hypersensitivity to iodinated contrast media; manifest hyperthyroidism. The injection must not be given intrathecally.

Warnings and precautions

Hypersensitivity and anaphylactoid reactions may occur, so resuscitation facilities should be available; risk is higher with a history of asthma or previous contrast reaction. Contrast-induced nephropathy may occur, particularly in renal impairment, diabetes and dehydration; ensure adequate hydration. Oral use of the hyperosmolar solution can cause fluid shift and dehydration and, if aspirated, pulmonary oedema.

Pregnancy

Use only if essential; iodinated contrast may affect fetal thyroid function, so neonatal thyroid function should be checked after exposure.

Storage and supply

Store below 25 °C, protected from light and X-rays.

Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.