Technetium (Sup99m/Suptc) Pentetic Acid

What it is and how it works

Technetium-99m pentetate is a small hydrophilic chelate that distributes in extracellular fluid and is excreted almost entirely by glomerular filtration without tubular secretion or reabsorption. This allows dynamic renal imaging and measurement of glomerular filtration rate; as an aerosol it is used to image lung ventilation.

Indications

Dynamic renal scintigraphy (perfusion, function and urinary outflow) and estimation of glomerular filtration rate; lung ventilation imaging by aerosol inhalation; brain scintigraphy for blood–brain barrier disruption and other uses according to licence.

Dosage and administration (summary)

Dosing (administered activity) is individualised according to protocol by the nuclear medicine specialist; given by intravenous injection or as a nebulised aerosol for ventilation studies, after radiolabelling with sodium pertechnetate (99mTc).

Contraindications

Hypersensitivity to the active substance or any kit component.

Warnings and precautions

Adequate hydration before renal studies is required for reliable results; diuretics or other drugs affecting renal function may alter findings. Radiolabelling and quality control must follow the product instructions, and radiation exposure should be kept as low as reasonably achievable.

Pregnancy

Diagnostic radiopharmaceuticals should be avoided in pregnancy unless clearly necessary; exclude pregnancy before administration in women of childbearing potential.

Storage and supply

Store the unlabelled kit according to the manufacturer (typically below 25 °C or at 2–8 °C); after labelling, keep the preparation in lead shielding and use within the time stated in the product information.

Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.