18f-fbp

What it is and how it works

18F-FBP (florbetapir F 18) is a positron-emitting tracer that crosses the blood–brain barrier and binds to fibrillar β-amyloid plaques. PET imaging of its distribution provides an estimate of cerebral β-amyloid neuritic plaque density.

Indications

PET imaging of the brain to estimate β-amyloid plaque density in adults with cognitive impairment being evaluated for Alzheimer’s disease and other causes of cognitive decline, as an adjunct to other diagnostic evaluations.

Dosage and administration (summary)

Dosing is individualised according to the imaging protocol and administered by nuclear medicine specialists as a single intravenous bolus; activity is measured in a dose calibrator before administration.

Contraindications

Hypersensitivity to the active substance or excipients.

Warnings and precautions

A positive scan does not by itself establish a diagnosis of Alzheimer’s disease, and images should be interpreted only by readers trained in the method. Radiation exposure should be kept as low as reasonably achievable, and patients should be well hydrated and void frequently after the scan.

Pregnancy

Generally avoided in pregnancy unless the diagnostic information is essential, because of fetal radiation exposure.

Storage and supply

Store at room temperature in appropriate radiation shielding in accordance with national regulations on radioactive materials; use within the short shelf-life stated on the label.

Source: reference summary prepared from the EU SmPC/EPAR, BNF and WHO Model Formulary. The approved product information in Iran governs.